Description
Recommended Use
The UltiMate 3000 Rapid Separation Quaternary system is an excellent choice for laboratories that want outstanding UHPLC technology but which still need to maintain established LC methods developed on quaternary systems. It is suitable for use with both ultra-high resolution and conventional columns with particles sizes ranging from sub-2μm to 10µm. It handles a range of separations from 2mm column internal diameters to small scale semi-prep or purification experiments.
Typical application areas are fast but highly resolving methods in drug development, academic research, high-throughput quality control, chemicals development and demanding mass spectrometry workflows. The UltiMate 3000 Rapid Separation Quaternary system is highly recommended for methods using either conventional 3-5µm or UHPLC, sub-2µm particle columns where moderately fast gradient response is acceptable for the benefit of improved mobile phase flexibility (i.e., multiple solvents, extended column wash, ternary or quaternary gradients and method development).
Ensuring Excellent Chromatography
- Up to 8 mL/min flow rate supporting up to 100 Mpa (15000 psi/1000 bar) backpressure for column format and column particle size flexibility. Manage backpressure and fine tune resolution with column heating and cooling from 5°C up to 110°C (mobile phase preheater and post-column cooler included)
- Obtain near-zero dead volume for optimal peak shapes even over extended periods using Thermo Scientific™ Dionex™ Viper™ Fingertight Fitting system (recommended)
- Minimizes contamination between samples for more accurate results with the ultra-low carryover autosamplers (with loop and needle permanently in the flow path)
- Get precise and accurate flow rates for stable retention times, robust peak integration, and confident identification from the Thermo Scientific™ Dionex™ SmartFlow™ technology
- Lets you optimize mixing efficiency with adjustable gradient delay volumes using Thermo Scientific™ Dionex™ SpinFlow technology
- Transfer methods between systems with confidence: the UltiMate Quaternary Rapid Separation System shares an identical system delay volume with the Quaternary Standard System by design
Chromeleon CDS Software Makes Operation Easy
- Integrated service and validation monitoring with Thermo Scientific™ Dionex™ Chromeleon™ CDS, versions 6.x and 7.x
- Automated system startup, standby and shutdown with Chromeleon CDS, versions 6.x and 7.x
- Compatible with Chromeleon 7.x eWorkflow walk-up solution and advanced reporting features
Choose the Right Configuration for You
- Four-solvent channel quaternary pump with integrated four-channel degasser (LPG-3400RS)
- Spacious solvent rack for large mobile phase bottles (SR-3000)
- Thermostatted or nonthermostatted autosamplers (WPS-3000TSL/WPS-3000SL)
- Thermostatted column compartment with up to two field upgradable column switching valves, (TCC-3000RS)
- Diode array, multiple wavelength, variable wavelength, fluorescence, charged aerosol, refractive index or mass spectrometry detectors
- Fraction collector (AFC-3000)
- Chromeleon 7.2 CDS software packages (standalone, networked, remote data processing and/or control)
- UltiMate™ 3000 Standard Dual System
Increase the speed and throughput of your LC and UHPLC workflows without redeveloping existing methods. The Thermo Scientific™ UltiMate™ 3000 Standard Dual System offers numerous options for improving the information yield of your analyses and can still be operated as a regular single-channel system. The dual system makes it easy to configure Online-SPE, Orthogonal, Parallel or Tandem separations, Inverse Gradient operations and Fast Application Switching. With its two fully integrated, independently operating gradient pumps and smart column switching, you can configure your system to maximize throughput, resolution, or sensitivity.
Recommended Use
For laboratories improving sample throughput for their LC and entry level UHPLC applications. Automating sample clean-up, establishing multiple LC and UHPLC methods on one system and taking advantage of Parallel and Tandem LC offer significant productivity improvements. Users can lower detection limits, apply advanced 2D-LC and UHPLC techniques, increase peak resolution, extend column life times, develop more robust methods and produce more high-quality data within a single system setup.
Typical application areas are QA/QC for pharmaceutical, food and beverage, and personal care products. The ability to run inverse gradients in parallel addresses the inherent challenges of nebulizer-based detection technologies e.g., LC/ESI-MS, charged aerosol detection, by providing a consistent mobile phase mix to the nebulizer source post-separation to ensure accurate results.
Ensuring Excellent Chromatography
- Two independently operating ternary gradient pumps (integrated module) each deliver up to 10 mL/min supporting up to 62 MPa (9000 psi/620 bar) for exceptional colum format and particle size flexibility
- Ultralow carryover sharable autosamplers (with loop and needle permanently in the flow path) deliver high precision injections and minimize contamination between samples for more accurate results
- Improves retention time precision by using a spacious and shared column compartment that keeps columns and samples at constant temperature (5°C to 80°C)
- Get near-zero dead volume for optimal peak shapes even over extended periods by using Thermo Scientific™ Dionex™ Viper™ fingertight fitting system
- Precise and accurate flow rates for stable retention times, robust peak integration, and confident identification using Thermo Scientific™ Dionex™ SmartFlow™ technology
- Optimize mixing efficiency with adjustable gradient delay volumes using Thermo Scientific™ Dionex™ SpinFlow™ technology
Chromeleon CDS Software Makes Operation Easy
- Integrated service and validation monitoring with Thermo Scientific™ Dionex™ Chromeleon™ CDS software, versions 6.x and 7.x
- Automated system startup, standby, method switching and shutdown with Chromeleon CDS, versions 6.x and 7.x
- Compatible with Chromeleon 7.x eWorkflow walk-up solution and advanced reporting features
Choose the Right Configuration for You
- Two 3-solvent channel pumps for versatile gradient methods (DGP-3600SD)
- Solvent rack with integrated 6-channel degasser (SRD-3600)
- Thermostatted or nontherostatted autosamplers (WPS-3000TSL/WPS-3000SL)
- Thermostatted column compartment with up to two field-upgradable column switching valves (TCC-3000SD), large variety of valve pods available
- Diode array, multiple wavelength, variable wavelength, fluorescence, charged aerosol, refractive index or mass spectrometry detectors
- Viper technology based solution/application kits for Online-SPE, Parallel (UHP)LC, Tandem (UHP)LC, Inverse Gradient Operation and Fast Application Switching
- Fraction collector (AFC-3000)
- [Bullet 8] Chromeleon 7.2 software packages (standalone, networked, remote data processing and/or control)
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