Description

Through a thorough redesign of the mechanical base frame and system enclosure, the microscope height has been reduced to below 3 m, which allows for instrument installation in labs with a ceiling height below 3.04 m (~10 ft), preventing costly room renovations. Built-in connectivity ensures a robust and risk-free pathway throughout the entire workflow, from sample preparation and optimization to image acquisition and data processing.

Solve structures at record-breaking resolutions
⦁ Pair the Krios G4 Cryo-TEM with the Thermo Scientific E-CFEG and the groundbreaking Thermo Scientific Selectris and Selectris X Imaging Filters to advance cryo-EM discovery with unprecedented resolution, speed, and ease of use.
⦁ The E-CFEG is a cold field emission gun with a narrow energy spread that results in higher contrast images and enables atomic resolution. This add-on makes it possible to efficiently solve structures at resolutions of 2.0 Å or less.
⦁ Selectris Imaging Filters provide unique stability, accessibility, and performance. Paired with the Thermo Scientific Falcon 4 Direct Electron Detector, these two add-ons produce better quality images up to 10 times faster than the previous generation.
⦁ An article published in Nature details how structural biologists used a Krios Cryo-TEM equipped with a Selectris Imaging Filter prototype to study protein structures at never-before-achieved resolutions, obtaining a 1.2 Å resolution structure of the iron-storing protein apoferritin and a 1.7 Å resolution of the GABA type A receptor-associated protein, with an even sharper resolution in key parts of the protein.

Key Features

⦁ See the throughput impact of the Falcon 4 Direct Electron Detector with 10 times shorter exposure times than previous generations.

⦁ Aberration-free image shift (AFIS) is an optical mode for faster data acquisition without comprising image quality. AFIS performs large beam shifts without off-axis coma and astigmatism.

⦁ Acquire more images per sample area with fringe-free imaging (FFI), enhancing your daily data throughput.

⦁ Make the most of your day with enhanced automation for acquisition setup, system remote monitoring to optimize microscope utilization, on-the-fly imaging with quality monitoring, and data management and project administration.